Intratumoural pks Escherichia coli is associated with risk of metachronous colorectal cancer and adenoma development in people with Lynch syndrome

YL Chu; P Georgeson; M Clendenning; K Mahmood; R Walker; J Como; S Joseland; SG Preston; T Rice; BM Lynch; RL Milne; MC Southey; GG Giles; AI Phipps; JL Hopper; AK Win; C Rosty; FA Macrae; I Winship; MA Jenkins; DD Buchanan; JE Joo

Journal article

Intratumoural pks Escherichia coli is associated with risk of metachronous colorectal cancer and adenoma development in people with Lynch syndrome

YL Chu, P Georgeson, M Clendenning, K Mahmood, R Walker, J Como, S Joseland, SG Preston, T Rice, BM Lynch, RL Milne, MC Southey, GG Giles, AI Phipps, JL Hopper, AK Win, C Rosty, FA Macrae, I Winship, MA Jenkins Show all

EBioMedicine | Elsevier | Published : 2025

DOI: 10.1016/j.ebiom.2025.105661

Download PDF

Abstract

Background: The adverse gut microbiome may underlie the variability in risks of colorectal cancer (CRC) and metachronous CRC in people with Lynch syndrome (LS). The role of pks+/− Escherichia coli (pks+/− E. coli), Enterotoxigenic Bacteroides fragilis (ETBF), and Fusobacterium nucleatum (Fn) in CRCs and adenomas in people with LS is unknown. Methods: A total of 358 LS cases, including 386 CRCs, 90 adenomas, 195 normal colonic mucosa DNA from the Australasian Colon Cancer Family Registry were tested using multiplex TaqMan qPCR. Logistic regression was used to compare the intratumoural prevalence of each bacteria in Lynch CRCs with 1336 sporadic CRCs. Cox proportional-hazards regression estima..

View full abstract